Years ago, all of the ghosts in a haunted schoolhouse were banished by a certain student. Now, they're back—and they want revenge... Satsuki and Keiichirou Miyanoshita are two siblings recovering from the tragic loss of their mother. After moving to their mother's hometown, they learn that the local school they have transferred to is an old building—one said to be haunted. Despite initially brushing it off as a silly rumor, the two soon discover that ghosts are indeed real and that they're after them! Gakkou no Kaidan is the creepy tale of the lives of these siblings and their newfound friends as they try to survive the school's ghosts—with a little help from their pet cat along the way.

Gakkou no Kaidan is notable for having an English dub by ADV Films that utlized a comedic script as opposed to the original serious one.